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It can help people lose an average of 16.6% of their starting weight over 64 weeks orlistat, also available under the brand name Xenical, works by stopping some of the fat you eat from being absorbed, helping 37% of people lose at least 5% of their body weight after 12 weeks alli is an over-the-counter version of orlistat, which can be obtained without a prescription if you meet certain criteria Mysimba is a weight loss pill that contains the active ingredients bupropion and naltrexone, which work to reduce your appetite, supporting an average of 8.1% weight loss after 56 weeks Note: For any weight loss medication to be effective, you will need to make lifestyle changes, such as eating a healthy, balanced, calorie-controlled diet and engaging in regular exercise
